1RL8
Crystal structure of the complex of resistant strain of hiv-1 protease(v82a mutant) with ritonavir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | protease RETROPEPSIN | polymer | 99 | 10689.6 | 2 | UniProt (P03367) Pfam (PF00077) | Human immunodeficiency virus 1 | HIV-1 PROTEASE |
| 2 | C (A) | RITONAVIR | non-polymer | 720.9 | 1 | BIRD (PRD_001001) Chemie (RIT) PubChem (5076) PubChem (60954) PubChem (392622) PubChem (10395099) PubChem (44325718) PubChem (45266310) PubChem (16760215) PubChem (455315) PubChem (92402731) PubChem (93535511) PubChem (93535509) PubChem (53487909) PubChem (54103495) PubChem (9853294) PubChem (135172324) PubChem (58662536) PubChem (66509020) PubChem (72942039) PubChem (72942040) PubChem (90717239) PubChem (93535510) PubChem (123133890) PubChem (133662525) PubChem (134602828) PubChem (134751724) PubChem (141861627) PubChem (169446189) PubChem (169446190) PubChem (170130299) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 143 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03367)
| PDB | External Database | Details |
|---|---|---|
| Ala 41 | Arg 109 | variant |
| Ala 82 | Val 150 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21379.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 720.9 | |
| All* | Total formula weight | 22100.1 |
