1RL8
Crystal structure of the complex of resistant strain of hiv-1 protease(v82a mutant) with ritonavir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | protease RETROPEPSIN | polymer | 99 | 10689.6 | 2 | UniProt (P03367) Pfam (PF00077) | Human immunodeficiency virus 1 | HIV-1 PROTEASE |
| 2 | C (A) | RITONAVIR | non-polymer | 720.9 | 1 | BIRD (PRD_001001) Chemie (RIT) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 143 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03367)
| PDB | External Database | Details |
|---|---|---|
| Ala 41 | Arg 109 | variant |
| Ala 82 | Val 150 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21379.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 720.9 | |
| All* | Total formula weight | 22100.1 |
