1R6U
Crystal structure of an active fragment of human tryptophanyl-tRNA synthetase with cytokine activity
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tryptophanyl-tRNA synthetase | polymer | 437 | 50158.1 | 2 | UniProt (P23381) Pfam (PF00458) Pfam (PF00579) | Homo sapiens (human) | Tryptophan-tRNA ligase, TrpRS, IFP53, hWRS |
| 2 | C (A) | TRYPTOPHANYL-5'AMP | non-polymer | 533.4 | 1 | Chemie (TYM) | |||
| 3 | D, E (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) PubChem (753) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 100 | Chemie (HOH) |
Sequence modifications
A, B: 48 - 471 (UniProt: P23381)
| PDB | External Database | Details |
|---|---|---|
| Mse 143 | Met 143 | modified residue |
| Mse 169 | Met 169 | modified residue |
| Mse 195 | Met 195 | modified residue |
| Gly 213 | Ser 213 | engineered mutation |
| Asp 214 | Tyr 214 | engineered mutation |
| Mse 241 | Met 241 | modified residue |
| Mse 243 | Met 243 | modified residue |
| Mse 319 | Met 319 | modified residue |
| Mse 350 | Met 350 | modified residue |
| Mse 401 | Met 401 | modified residue |
| Mse 425 | Met 425 | modified residue |
| Mse 461 | Met 461 | modified residue |
| Lys 472 | - | cloning artifact |
| Leu 473 | - | cloning artifact |
| Ala 474 | - | cloning artifact |
| Ala 475 | - | cloning artifact |
| Ala 476 | - | cloning artifact |
| Leu 477 | - | cloning artifact |
| Glu 478 | - | cloning artifact |
| His 479 | - | expression tag |
| His 480 | - | expression tag |
| His 481 | - | expression tag |
| His 482 | - | expression tag |
| His 483 | - | expression tag |
| His 484 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 100316.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 717.6 | |
| All* | Total formula weight | 101033.8 |
