1R2B
Crystal structure of the BCL6 BTB domain complexed with a SMRT co-repressor peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | B-cell lymphoma 6 protein | polymer | 127 | 14559.8 | 2 | UniProt (P41182) Pfam (PF00651) | Homo sapiens (human) | BCL-6, Zinc finger protein 51, LAZ-3 protein, POZ domain, BTB/POZ domain |
| 2 | C, D (C, D) | Nuclear receptor co-repressor 2 | polymer | 19 | 2024.3 | 2 | UniProt (Q9Y618) | Homo sapiens (human) | N-CoR2, Silencing mediator of retinoic acid and thyroid hormone receptor, SMRT, SMRTe, Thyroid-, retinoic-acid-receptor-associated co-repressor, T3 receptor- associating factor, TRAC, CTG repeat protein 26 |
| 3 | E, F, G, H (A, B, C, D) | water | water | 18.0 | 130 | Chemie (HOH) |
Sequence modifications
A, B: 5 - 129 (UniProt: P41182)
C, D: 1414 - 1430 (UniProt: Q9Y618)
| PDB | External Database | Details |
|---|---|---|
| Gly 3 | - | cloning artifact |
| Ser 4 | - | cloning artifact |
| Gln 8 | Cys 8 | engineered mutation |
| Arg 67 | Cys 67 | engineered mutation |
| Asn 84 | Cys 84 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | cloning artifact |
| Ser 0 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 33168.3 | |
| All* | Total formula weight | 33168.3 |
