1QA7
CRYSTAL COMPLEX OF THE 3C PROTEINASE FROM HEPATITIS A VIRUS WITH ITS INHIBITOR AND IMPLICATIONS FOR THE POLYPROTEIN PROCESSING IN HAV
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | HAV 3C PROTEINASE | polymer | 217 | 23828.5 | 4 | UniProt (P26582) Pfam (PF00548) UniProt (by SIFTS) (P08617) | Hepatitis A virus | |
| 2 | E, F, G, H (A, B, C, D) | N-(iodoacetyl)-L-valyl-L-phenylalaninamide | non-polymer | 431.3 | 4 | Chemie (IVF) | |||
| 3 | I (D) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 4 | J (D) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | K, L, M, N (A, B, C, D) | water | water | 18.0 | 514 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 217 (UniProt: P26582)
| PDB | External Database | Details |
|---|---|---|
| Ser 24 | Cys 1542 | engineered mutation |
| Ala 82 | Phe 1600 | engineered mutation |
| Gln 101 | Glu 1619 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 95313.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1895.3 | |
| All* | Total formula weight | 97209.2 |
