1Q6S
THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEX WITH COMPOUND 9
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Protein-tyrosine phosphatase, non-receptor type 1 | polymer | 310 | 36238.2 | 2 | UniProt (P18031) Pfam (PF00102) In PDB | Homo sapiens (human) | Protein-tyrosine phosphatase 1B, PTP-1B |
| 2 | A, B | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 3 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | A, B | 6-[4-((2R)-2-(1H-1,2,3-BENZOTRIAZOL-1-YL)-3-{4-[DIFLUORO(PHOSPHONO)METHYL]PHENYL}-2-PHENYLPROPYL)PHENYL]-2-METHYLQUINOLIN-8-YLPHOSPHONIC ACID | non-polymer | 740.6 | 2 | Chemie (214) | |||
| 5 | A | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 1 | Chemie (MPD) | |||
| 6 | water | water | 18.0 | 396 | Chemie (HOH) |
Sequence modifications
A, B: 501 - 798 (UniProt: P18031)
| PDB | External Database | Details |
|---|---|---|
| Met 489 | - | cloning artifact |
| Asp 490 | - | cloning artifact |
| Tyr 491 | - | cloning artifact |
| Lys 492 | - | cloning artifact |
| Asp 493 | - | cloning artifact |
| Asp 494 | - | cloning artifact |
| Asp 495 | - | cloning artifact |
| Asp 496 | - | cloning artifact |
| Lys 497 | - | cloning artifact |
| Leu 498 | - | cloning artifact |
| Glu 499 | - | cloning artifact |
| Phe 500 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 72476.3 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1754.4 | |
| All* | Total formula weight | 74230.7 |
