Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0016311 | biological_process | dephosphorylation |
| B | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| B | 0006470 | biological_process | protein dephosphorylation |
| B | 0016311 | biological_process | dephosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 2011 |
| Chain | Residue |
| A | ARG545 |
| A | LEU619 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 2012 |
| Chain | Residue |
| B | ARG1045 |
| B | ALA1122 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 2013 |
| Chain | Residue |
| A | HOH3307 |
| B | ARG1047 |
| B | 2141301 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 4000 |
| Chain | Residue |
| A | HOH4003 |
| A | HOH4004 |
| A | HOH4005 |
| A | HOH4006 |
| A | HOH4001 |
| A | HOH4002 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MG B 5000 |
| Chain | Residue |
| B | HIS1054 |
| B | HOH3185 |
| B | HOH5001 |
| B | HOH5002 |
| B | HOH5003 |
| B | HOH5004 |
| B | HOH5005 |
| B | HOH5006 |
| site_id | AC6 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE 214 A 801 |
| Chain | Residue |
| A | ARG524 |
| A | SER528 |
| A | ASP529 |
| A | TYR546 |
| A | ARG547 |
| A | ASP548 |
| A | ASP681 |
| A | PHE682 |
| A | CYS715 |
| A | SER716 |
| A | ALA717 |
| A | GLY718 |
| A | ILE719 |
| A | GLY720 |
| A | ARG721 |
| A | ARG754 |
| A | MET758 |
| A | GLN762 |
| A | HOH3005 |
| A | HOH3027 |
| A | HOH3031 |
| A | HOH3110 |
| A | HOH3194 |
| A | HOH3265 |
| B | ALA1018 |
| B | GLN1021 |
| B | ASP1022 |
| site_id | AC7 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE 214 B 1301 |
| Chain | Residue |
| A | ALA518 |
| A | ASP522 |
| A | HIS525 |
| A | GLU526 |
| B | ARG1024 |
| B | SER1028 |
| B | ASP1029 |
| B | TYR1046 |
| B | ARG1047 |
| B | ASP1048 |
| B | LEU1119 |
| B | PHE1182 |
| B | CYS1215 |
| B | SER1216 |
| B | ALA1217 |
| B | GLY1218 |
| B | ILE1219 |
| B | GLY1220 |
| B | ARG1221 |
| B | ARG1254 |
| B | MET1258 |
| B | GLY1259 |
| B | GLN1262 |
| B | CL2013 |
| B | HOH3033 |
| B | HOH3036 |
| B | HOH3058 |
| B | HOH3064 |
| B | HOH3073 |
| B | HOH3120 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MPD A 6000 |
| Chain | Residue |
| A | ARG524 |
| A | HOH3097 |
| A | HOH3103 |
| B | ALA1017 |
| B | TYR1020 |
| B | ARG1024 |
Functional Information from PROSITE/UniProt
| site_id | PS00383 |
| Number of Residues | 11 |
| Details | TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGigRSG |
| Chain | Residue | Details |
| A | VAL713-GLY723 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Phosphocysteine intermediate |
| Chain | Residue | Details |
| A | CYS715 | |
| B | CYS1215 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ASP681 | |
| B | ASP1181 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS715 | |
| A | GLN762 | |
| B | CYS1215 | |
| B | GLN1262 | |
| Chain | Residue | Details |
| A | MET501 | |
| B | MET1001 | |
| Chain | Residue | Details |
| A | TYR520 | |
| B | TYR1020 | |
| Chain | Residue | Details |
| A | SER550 | |
| B | SER1050 | |
| Chain | Residue | Details |
| A | TYR566 | |
| B | TYR1066 | |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: S-nitrosocysteine; in reversibly inhibited form => ECO:0000269|PubMed:22169477 |
| Chain | Residue | Details |
| A | CYS715 | |
| B | CYS1215 | |
| Chain | Residue | Details |
| A | SER742 | |
| A | SER743 | |
| B | SER1242 | |
| B | SER1243 | |
| Chain | Residue | Details |
| A | CYS715 | |
| A | SER716 | |
| B | CYS1215 | |
| B | SER1216 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1d5r |
| Chain | Residue | Details |
| A | ARG721 | |
| A | CYS715 | |
| A | ASP681 | |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1d5r |
| Chain | Residue | Details |
| B | ASP1181 | |
| B | ARG1221 | |
| B | CYS1215 | |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1d5r |
| Chain | Residue | Details |
| A | ARG721 | |
| A | SER722 | |
| A | CYS715 | |
| A | ASP681 | |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1d5r |
| Chain | Residue | Details |
| B | ASP1181 | |
| B | SER1222 | |
| B | ARG1221 | |
| B | CYS1215 | |
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 469 |
| Chain | Residue | Details |
| A | ASP681 | proton shuttle (general acid/base) |
| A | CYS715 | covalent catalysis |
| A | ARG721 | activator, electrostatic stabiliser |
| A | SER722 | activator, electrostatic stabiliser |
| A | GLN762 | steric role |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 469 |
| Chain | Residue | Details |
| B | ASP1181 | proton shuttle (general acid/base) |
| B | CYS1215 | covalent catalysis |
| B | ARG1221 | activator, electrostatic stabiliser |
| B | SER1222 | activator, electrostatic stabiliser |
| B | GLN1262 | steric role |
