1OW0

Crystal structure of human FcaRI bound to IgA1-Fc

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Ig alpha-1 chain C region	polymer	214	23226.4	2	UniProt (P01876) Pfam (PF00047) Pfam (PF07654)	Homo sapiens (human)
2	C, D (C, D)	Immunoglobulin alpha Fc receptor	polymer	207	23615.7	2	UniProt (P24071) Pfam (PF00047)	Homo sapiens (human)	IgA Fc receptor, CD89 antigen
3	E (E)	N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1551.4	1	In PDB GlyTouCan (G95451PL)
4	F (F)	N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1551.4	1	In PDB GlyTouCan (G52095QZ)
5	G, J (G, J)	alpha-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	2	In PDB GlyTouCan (G08748CW)
6	H, K (H, K)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G35926TG)
7	I, L (I, L)	beta-D-mannopyranose-(1-4)-beta-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1073.0	2	In PDB GlyTouCan (G15110KA)
8	M, N (C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)

Sequence modifications

A, B: 241 - 454 (UniProt: P01876)

PDB	External Database	Details
Ala 241	Cys 122	engineered mutation

C, D: 1 - 195 (UniProt: P24071)

PDB	External Database	Details
Ala 196	-	expression tag
Ile 197	-	expression tag
Asp 198	-	expression tag
Gly 199	-	expression tag
Arg 200	-	expression tag
Ala 201	-	expression tag
His 202	-	expression tag
His 203	-	expression tag
His 204	-	expression tag
His 205	-	expression tag
His 206	-	expression tag
His 207	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	93684.3
Branched	Number of molecules	8
	Total formula weight	8243.5
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	102370.2

*Water molecules are not included.