1OPJ
Structural basis for the auto-inhibition of c-Abl tyrosine kinase
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Proto-oncogene tyrosine-protein kinase ABL1 | polymer | 293 | 33743.5 | 2 | UniProt (P00520) Pfam (PF07714) In PDB | Mus musculus (house mouse) | p150, c-ABL |
2 | A, B | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
3 | A, B | MYRISTIC ACID | non-polymer | 228.4 | 2 | Chemie (MYR) | |||
4 | A, B | 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE | non-polymer | 493.6 | 2 | Chemie (STI) | |||
5 | water | water | 18.0 | 231 | Chemie (HOH) |
Sequence modifications
A, B: 248 - 534 (UniProt: P00520)
PDB | External Database | Details |
---|---|---|
Gly 242 | - | cloning artifact |
Ala 243 | - | cloning artifact |
Met 244 | - | cloning artifact |
Asp 245 | - | cloning artifact |
Pro 246 | - | cloning artifact |
Ser 247 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 67487.0 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1514.9 | |
All* | Total formula weight | 69001.9 |