1OO4

P395S mutant of the p85 regulatory subunit of the N-terminal src homology 2 domain of PI3-Kinase complexed to a peptide derived from PDGFr

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Phosphatidylinositol 3-kinase regulatory alpha subunit	polymer	111	12860.3	1	UniProt (P23727) Pfam (PF00017) In PDB	Bos taurus (cattle)	PI3-kinase p85-alpha subunit
2	B	8-mer peptide from PDGFr	polymer	8	1003.1	1

Sequence modifications

A: 1 - 111 (UniProt: P23727)

PDB	External Database	Details
Ser 60	Leu 380	conflict
Ser 75	Pro 395	engineered mutation

Sequence viewer

Contents of the asymmetric unit

*Water molecules are not included.