1OG5

Structure of human cytochrome P450 CYP2C9

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	CYTOCHROME P450 2C9	polymer	475	54168.6	2	UniProt (P11712) Pfam (PF00067)	HOMO SAPIENS (HUMAN)	(R)-LIMONENE 6-MONOOXYGENASE, (S)-LIMONENE 6-MONOOXYGENASE, (S)-LIMONENE 7-MONOOXYGENASE, CYPIIC9, CYTOCHROME P-450MP, CYTOCHROME P450 MP-4, CYTOCHROME P450 MP-8, CYTOCHROME P450 PB-1, S-MEPHENYTOIN 4-HYDROXYLASE
2	C, E (A, B)	HEME C	non-polymer		618.5	2	Chemie (HEC)
3	D, F (A, B)	S-WARFARIN	non-polymer		308.3	2	Chemie (SWF)
4	G, H (A, B)	water	water		18.0	423	Chemie (HOH)

Sequence modifications

A, B: 20 - 29 (PDB: 1OG5)
A, B: 491 - 494 (PDB: 1OG5)
A, B: 30 - 490 (UniProt: P11712)

PDB	External Database	Details
Glu 206	Lys 206	engineered mutation
Val 215	Ile 215	engineered mutation
Tyr 216	Cys 216	engineered mutation
Pro 220	Ser 220	engineered mutation
Ala 221	Pro 221	engineered mutation
Leu 222	Ile 222	engineered mutation
Leu 223	Ile 223	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	108337.2
Non-Polymers*	Number of molecules	4
	Total formula weight	1853.7
All*	Total formula weight	110190.8

*Water molecules are not included.