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1OG5

Structure of human cytochrome P450 CYP2C9

Functional Information from GO Data
ChainGOidnamespacecontents
A0004497molecular_functionmonooxygenase activity
A0005506molecular_functioniron ion binding
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005886cellular_componentplasma membrane
A0006805biological_processxenobiotic metabolic process
A0008202biological_processsteroid metabolic process
A0008203biological_processcholesterol metabolic process
A0008210biological_processestrogen metabolic process
A0008392molecular_functionarachidonate epoxygenase activity
A0008395molecular_functionsteroid hydroxylase activity
A0008404molecular_functionarachidonate 14,15-epoxygenase activity
A0008405molecular_functionarachidonate 11,12-epoxygenase activity
A0016020cellular_componentmembrane
A0016098biological_processmonoterpenoid metabolic process
A0016491molecular_functionoxidoreductase activity
A0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A0016712molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
A0018675molecular_function(S)-limonene 6-monooxygenase activity
A0018676molecular_function(S)-limonene 7-monooxygenase activity
A0019369biological_processarachidonate metabolic process
A0019373biological_processepoxygenase P450 pathway
A0019627biological_processurea metabolic process
A0020037molecular_functionheme binding
A0032787biological_processmonocarboxylic acid metabolic process
A0034875molecular_functioncaffeine oxidase activity
A0042178biological_processxenobiotic catabolic process
A0042759biological_processlong-chain fatty acid biosynthetic process
A0043231cellular_componentintracellular membrane-bounded organelle
A0043603biological_processamide metabolic process
A0046456biological_processicosanoid biosynthetic process
A0046872molecular_functionmetal ion binding
A0052741molecular_function(R)-limonene 6-monooxygenase activity
A0070330molecular_functionaromatase activity
A0070989biological_processoxidative demethylation
A0097267biological_processomega-hydroxylase P450 pathway
B0004497molecular_functionmonooxygenase activity
B0005506molecular_functioniron ion binding
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005886cellular_componentplasma membrane
B0006805biological_processxenobiotic metabolic process
B0008202biological_processsteroid metabolic process
B0008203biological_processcholesterol metabolic process
B0008210biological_processestrogen metabolic process
B0008392molecular_functionarachidonate epoxygenase activity
B0008395molecular_functionsteroid hydroxylase activity
B0008404molecular_functionarachidonate 14,15-epoxygenase activity
B0008405molecular_functionarachidonate 11,12-epoxygenase activity
B0016020cellular_componentmembrane
B0016098biological_processmonoterpenoid metabolic process
B0016491molecular_functionoxidoreductase activity
B0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
B0016712molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
B0018675molecular_function(S)-limonene 6-monooxygenase activity
B0018676molecular_function(S)-limonene 7-monooxygenase activity
B0019369biological_processarachidonate metabolic process
B0019373biological_processepoxygenase P450 pathway
B0019627biological_processurea metabolic process
B0020037molecular_functionheme binding
B0032787biological_processmonocarboxylic acid metabolic process
B0034875molecular_functioncaffeine oxidase activity
B0042178biological_processxenobiotic catabolic process
B0042759biological_processlong-chain fatty acid biosynthetic process
B0043231cellular_componentintracellular membrane-bounded organelle
B0043603biological_processamide metabolic process
B0046456biological_processicosanoid biosynthetic process
B0046872molecular_functionmetal ion binding
B0052741molecular_function(R)-limonene 6-monooxygenase activity
B0070330molecular_functionaromatase activity
B0070989biological_processoxidative demethylation
B0097267biological_processomega-hydroxylase P450 pathway
Functional Information from PDB Data
site_idAC1
Number of Residues20
DetailsBINDING SITE FOR RESIDUE HEC A 501
ChainResidue
AARG97
ATHR305
AGLN356
ALEU362
ASER365
AHIS368
APRO427
APHE428
ASER429
AARG433
ACYS435
AVAL113
AALA441
ATRP120
AARG124
ALEU294
AALA297
AGLY298
ATHR301
ATHR302

site_idAC2
Number of Residues14
DetailsBINDING SITE FOR RESIDUE SWF A 502
ChainResidue
AARG97
AGLY98
APHE100
ALEU102
AVAL113
APHE114
ALEU208
AASN217
ATHR364
ASER365
ALEU366
APRO367
APHE476
AHOH2197

site_idAC3
Number of Residues21
DetailsBINDING SITE FOR RESIDUE HEC B 501
ChainResidue
BARG97
BILE112
BVAL113
BTRP120
BARG124
BALA297
BGLY298
BTHR301
BTHR302
BTHR305
BGLN356
BLEU362
BSER365
BHIS368
BPRO427
BPHE428
BSER429
BARG433
BCYS435
BALA441
BGLU444

site_idAC4
Number of Residues13
DetailsBINDING SITE FOR RESIDUE SWF B 502
ChainResidue
BARG97
BGLY98
BILE99
BPHE100
BLEU102
BALA103
BVAL113
BPHE114
BASN217
BTHR364
BSER365
BPRO367
BPHE476

Functional Information from PROSITE/UniProt
site_idPS00086
Number of Residues10
DetailsCYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FSaGKRICVG
ChainResidueDetails
APHE428-GLY437

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: axial binding residue
ChainResidueDetails
ACYS435
BCYS435

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1akd
ChainResidueDetails
AGLU300
ATHR301

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1akd
ChainResidueDetails
BGLU300
BTHR301

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PDB entries from 2024-10-30

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