1O7D
The structure of the bovine lysosomal a-mannosidase suggests a novel mechanism for low pH activation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Lysosomal alpha-mannosidase | polymer | 298 | 34527.2 | 1 | UniProt (Q29451) Pfam (PF01074) | Bos taurus (Bovine) | Laman,Lysosomal acid alpha-mannosidase,Mannosidase alpha class 2B member 1,Mannosidase alpha-B |
| 2 | B (B) | Lysosomal alpha-mannosidase | polymer | 84 | 9649.9 | 1 | UniProt (Q29451) Pfam (PF09261) | Bos taurus (Bovine) | Laman,Lysosomal acid alpha-mannosidase,Mannosidase alpha class 2B member 1,Mannosidase alpha-B |
| 3 | C (C) | Lysosomal alpha-mannosidase | polymer | 159 | 17596.1 | 1 | UniProt (Q29451) Pfam (PF09261) Pfam (PF21260) | Bos taurus (Bovine) | Laman,Lysosomal acid alpha-mannosidase,Mannosidase alpha class 2B member 1,Mannosidase alpha-B |
| 4 | D (D) | Lysosomal alpha-mannosidase | polymer | 282 | 32225.5 | 1 | UniProt (Q29451) Pfam (PF07748) | Bos taurus (Bovine) | Laman,Lysosomal acid alpha-mannosidase,Mannosidase alpha class 2B member 1,Mannosidase alpha-B |
| 5 | E (E) | Lysosomal alpha-mannosidase | polymer | 126 | 14054.8 | 1 | UniProt (Q29451) Pfam (PF17677) | Bos taurus (Bovine) | Laman,Lysosomal acid alpha-mannosidase,Mannosidase alpha class 2B member 1,Mannosidase alpha-B |
| 6 | F (F) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1559.4 | 1 | In PDB GlyTouCan (G83161QT) | |||
| 7 | G, H, I (G, H, I) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 8 | J (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 9 | K (A) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
| 10 | L (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 11 | M, N (A, E) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 12 | O, P, Q, R, S (A, B, C, D, E) | water | water | 18.0 | 39 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 108053.5 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 2832.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 600.9 | |
| All* | Total formula weight | 111487.0 |
