1O5D
Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | Coagulation factor VII | polymer | 152 | 17047.0 | 1 | UniProt (P08709) Pfam (PF00594) Pfam (PF00008) Pfam (PF14670) | Homo sapiens (human) | Serum prothrombin conversion accelerator, Eptacog alfa |
| 2 | B (H) | Coagulation factor VII | polymer | 254 | 28103.3 | 1 | UniProt (P08709) Pfam (PF00089) | Homo sapiens (human) | Serum prothrombin conversion accelerator, Eptacog alfa |
| 3 | C (T) | Tissue factor | polymer | 218 | 24739.4 | 1 | UniProt (P13726) Pfam (PF01108) Pfam (PF09294) | Homo sapiens (human) | TF, Coagulation factor III, Thromboplastin, CD142 antigen |
| 4 | D (H) | 2-{5-[AMINO(IMINIO)METHYL]-6-FLUORO-1H-BENZIMIDAZOL-2-YL}-6-[(2-METHYLCYCLOHEXYL)OXY]BENZENOLATE | non-polymer | 382.4 | 1 | Chemie (CR9) | |||
| 5 | E, F, G (L, H, T) | water | water | 18.0 | 588 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 69889.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 382.4 | |
| All* | Total formula weight | 70272.1 |
