1O27

Crystal structure of Thymidylate Synthase Complementing Protein (TM0449) from Thermotoga maritima with FAD and BrdUMP at 2.3 A resolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Thymidylate synthase thyX	polymer	232	27503.7	4	UniProt (Q9WYT0) Pfam (PF02511)	Thermotoga maritima	TS, TSase, thymidylate synthase complementing protein
2	E, G, J, L (A, B, C, D)	5-BROMO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE	non-polymer		387.1	4	Chemie (BRU)
3	F, H, I, K (A, B, C, D)	FLAVIN-ADENINE DINUCLEOTIDE	non-polymer		785.5	4	Chemie (FAD)
4	M, N, O, P (A, B, C, D)	water	water		18.0	201	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 220 (UniProt: Q9WYT0)

PDB	External Database	Details
Met -11	-	expression tag
Gly -10	-	expression tag
Ser -9	-	expression tag
Asp -8	-	expression tag
Lys -7	-	expression tag
Ile -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	110014.7
Non-Polymers*	Number of molecules	8
	Total formula weight	4690.5
All*	Total formula weight	114705.2

*Water molecules are not included.