1O1T
Structure of FPT bound to the CVIM-FPP product
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein farnesyltransferase alpha subunit | polymer | 380 | 44368.4 | 1 | UniProt (Q04631) Pfam (PF01239) | Rattus norvegicus (Norway rat) | CAAX farnesyltransferase alpha subunit, RAS proteins prenyltransferase alpha, FTase-alpha |
| 2 | B (B) | Protein farnesyltransferase beta subunit | polymer | 427 | 47749.3 | 1 | UniProt (Q02293) Pfam (PF00432) | Rattus norvegicus (Norway rat) | CAAX farnesyltransferase beta subunit, RAS proteins prenyltransferase beta, FTase-beta |
| 3 | C (B) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | D (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | E (B) | N-ACETYL-S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL]-L-CYSTEINYL-D-VALYL-L-ISOLEUCYL-L-METHIONINE | non-polymer | 711.0 | 1 | Chemie (2NH) | |||
| 6 | F, G (A, B) | water | water | 18.0 | 652 | Chemie (HOH) |
Sequence modifications
A: 1 - 377 (UniProt: Q04631)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | cloning artifact |
| Ser -1 | - | cloning artifact |
| His 0 | - | cloning artifact |
| Thr 156 | Ile 156 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 92117.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 800.7 | |
| All* | Total formula weight | 92918.4 |
