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1O0V

The crystal structure of IgE Fc reveals an asymmetrically bent conformation

Replaces:  1LS0
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Immunoglobulin heavy chain epsilon-1polymer32736338.82GenBank (386807)
Pfam (PF07654)
UniProt (by SIFTS) (P01854)
Homo sapiens (human)IgE fc
2C
(C)
alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched1235.11In PDB
GlyTouCan (G55220VL)
3D
(D)
alpha-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched1235.11In PDB
GlyTouCan (G34059IB)
4E, F, G, H
(A)
SULFATE IONnon-polymer96.14Chemie (SO4)
5I, J
(A)
GLYCEROLnon-polymer92.12Chemie (GOL)
6K, L
(A, B)
waterwater18.0244Chemie (HOH)
Sequence modifications
A, B: 222 - 547 (GenBank: 386807)
PDBExternal DatabaseDetails
Ala 225Cys 251engineered mutation
Gln 265Asn 292engineered mutation
Gln 371Asn 398engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight72677.5
BranchedNumber of molecules2
Total formula weight2470.2
Non-Polymers*Number of molecules6
Total formula weight568.4
All*Total formula weight75716.2
*Water molecules are not included.

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PDB entries from 2025-06-11

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