1NVV
Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (Q) | Transforming protein p21/H-RAS-1 | polymer | 166 | 18783.1 | 1 | UniProt (P01112) Pfam (PF00071) | Homo sapiens (human) | C-H-RAS |
| 2 | B (R) | Transforming protein p21/H-RAS-1 | polymer | 166 | 18875.2 | 1 | UniProt (P01112) Pfam (PF00071) | Homo sapiens (human) | C-H-RAS |
| 3 | C (S) | Son of sevenless protein homolog 1 | polymer | 481 | 56532.7 | 1 | UniProt (Q07889) Pfam (PF00618) Pfam (PF00617) | Homo sapiens (human) | SOS-1 |
| 4 | D (Q) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | E, G, H, I, J (Q, R, S) | PHOSPHATE ION | non-polymer | 95.0 | 5 | Chemie (PO4) | |||
| 6 | F (Q) | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 1 | Chemie (GNP) | |||
| 7 | K, L, M (Q, R, S) | water | water | 18.0 | 315 | Chemie (HOH) |
Sequence modifications
Q: 1 - 166 (UniProt: P01112)
| PDB | External Database | Details |
|---|---|---|
| Ala 64 | Tyr 64 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 94191.0 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1021.4 | |
| All* | Total formula weight | 95212.4 |
