1NMA
N9 NEURAMINIDASE COMPLEXES WITH ANTIBODIES NC41 AND NC10: EMPIRICAL FREE-ENERGY CALCULATIONS CAPTURE SPECIFICITY TRENDS OBSERVED WITH MUTANT BINDING DATA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (N) | N9 NEURAMINIDASE | polymer | 388 | 43640.5 | 1 | UniProt (P05803) Pfam (PF00064) | Influenza A virus | |
| 2 | B (L) | FAB NC10 | polymer | 109 | 12129.3 | 1 | GenBank (501094) | Mus musculus (house mouse) | |
| 3 | C (H) | FAB NC10 | polymer | 122 | 13424.7 | 1 | GenBank (501094) | Mus musculus (house mouse) | |
| 4 | D (A) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G01760ZU) | |||
| 5 | E (N) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) |
Sequence modifications
N: 82 - 468 (UniProt: P05803)
L: 1 - 107 (GenBank: 501094)
H: 2 - 112 (GenBank: 501094)
| PDB | External Database | Details |
|---|---|---|
| Lys 387 | Arg 388 | conflict |
| Arg 389 | Lys 390 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gln 3 | Glu 161 | conflict |
| Met 4 | Leu 162 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Pro 7 | Ser 29 | conflict |
| Leu 109 | Val 140 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 69194.5 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 1073.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 221.2 | |
| All* | Total formula weight | 70488.7 |
