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1NKH

Crystal structure of Lactose synthase complex with UDP and Manganese

Replaces:  1J8X
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, C
(A, C)
ALPHA-LACTALBUMINpolymer12314015.82UniProt (P29752)
Pfam (PF00062)
Mus musculus (house mouse)LACTALBUMIN, ALPHA
2B, D
(B, D)
BETA-1,4-GALACTOSYLTRANSFERASEpolymer28632851.62UniProt (P08037)
Pfam (PF13733)
Pfam (PF02709)
Bos taurus (cattle)B4GAL-T1; BETA4GAL-T1; BETA-1,4-GALTASE 1; BETA-1,4-GALACTOSYLTRANSFERASE 1; UDP-GALACTOSE:BETA-N-ACETYLGLUCOSAMINE BETA-1,4-GALACTOSYLTRANSFERASE 1
3E, M
(A, C)
CALCIUM IONnon-polymer40.12Chemie (CA)
4F, P
(A, D)
SULFATE IONnon-polymer96.12Chemie (SO4)
5G, K, L, N, S
(A, B, C, D)
TETRAETHYLENE GLYCOLnon-polymer194.25Chemie (PG4)
6H, O
(B, D)
MANGANESE (II) IONnon-polymer54.92Chemie (MN)
7I, J, Q, R
(B, D)
URIDINE-5'-DIPHOSPHATEnon-polymer404.24Chemie (UDP)
8T, U, V, W
(A, B, C, D)
waterwater18.0608Chemie (HOH)
Sequence modifications
B, D: 130 - 402 (UniProt: P08037)
PDBExternal DatabaseDetails
Ala 117-SEE REMARK 999
Ser 118-SEE REMARK 999
Met 119-SEE REMARK 999
Thr 120-SEE REMARK 999
Gly 121-SEE REMARK 999
Gly 122-SEE REMARK 999
Gln 123-SEE REMARK 999
Gln 124-SEE REMARK 999
Met 125-SEE REMARK 999
Gly 126-SEE REMARK 999
Arg 127-SEE REMARK 999
Gly 128-SEE REMARK 999
Ser 129-SEE REMARK 999
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight93734.9
Non-Polymers*Number of molecules15
Total formula weight2969.9
All*Total formula weight96704.8
*Water molecules are not included.

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PDB entries from 2025-12-03

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