1ND5
Crystal Structures of Human Prostatic Acid Phosphatase in Complex with a Phosphate Ion and alpha-Benzylaminobenzylphosphonic Acid Update the Mechanistic Picture and Offer New Insights into Inhibitor Design
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | prostatic acid phosphatase | polymer | 354 | 41050.6 | 4 | UniProt (P15309) Pfam (PF00328) | Homo sapiens (human) | |
| 2 | E, F, G, H (E, F, G, H) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 3 | I (I) | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G62182OO) | |||
| 4 | J, O, R, V (A, B, C, D) | ALPHA-BENZYL-AMINOBENZYL-PHOSPHONIC ACID | non-polymer | 277.3 | 4 | Chemie (2BF) | |||
| 5 | K, L, M, P, Q... (A, B, C, D) | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 8 | Chemie (1PE) | |||
| 6 | N (B) | 2-acetamido-2-deoxy-alpha-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NDG) | |||
| 7 | U (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 8 | AA, X, Y, Z (D, A, B, C) | water | water | 18.0 | 135 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 164202.4 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 2284.1 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 3457.7 | |
| All* | Total formula weight | 169944.2 |
