1N95
Aryl Tetrahydrophyridine Inhbitors of Farnesyltranferase: Glycine, Phenylalanine and Histidine Derivatives
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Protein farnesyltransferase alpha subunit | polymer | 315 | 38016.7 | 1 | UniProt (Q04631) Pfam (PF01239) In PDB | Rattus norvegicus (Norway rat) | CAAX farnesyltransferase alpha subunit, RAS proteins prenyltransferase alpha, FTase-alpha |
2 | B | Protein farnesyltransferase beta subunit | polymer | 402 | 44976.4 | 1 | UniProt (Q02293) Pfam (PF00432) In PDB | Rattus norvegicus (Norway rat) | CAAX farnesyltransferase beta subunit, RAS proteins prenyltransferase beta, FTase-beta |
3 | B | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
4 | B | ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID | non-polymer | 308.4 | 1 | Chemie (HFP) | |||
5 | B | 1-[2-(4-CYANO-BENZYLAMINO)-3-(3-METHYL-3H-IMIDAZOL-4-YL)-PROPIONYL]-5-NAPHTHALEN-1-YL-1,2,3,6-TETRAHYDRO-PYRIDINE-4-CARBONITRILE | non-polymer | 500.6 | 1 | Chemie (FTH) |
Sequence modifications
A: 55 - 369 (UniProt: Q04631)
PDB | External Database | Details |
---|---|---|
Thr 156 | Ile 156 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 82993.1 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 874.4 | |
All* | Total formula weight | 83867.5 |