1MX5
Crystal Structure of Human Liver Carboxylesterase in complexed with homatropine, a cocaine analogue
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | liver Carboxylesterase I | polymer | 548 | 60511.3 | 6 | UniProt (P23141) Pfam (PF00135) | Homo sapiens (human) | hCEv, Acyl coenzyme A:cholesterol acyltransferase, ACAT, Monocyte/macrophage serine esterase, HMSE, Serine esterase 1 |
| 2 | AA, G, L, P, S... (F, A, B, C, D...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 7 | Chemie (NAG) | |||
| 3 | BA, H, M (F, A, B) | N-acetyl-alpha-neuraminic acid | non-polymer | 309.3 | 3 | Chemie (SIA) | |||
| 4 | I, X (A, E) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | CA, DA, J, K, N... (F, A, B, C, D...) | HOMOTROPINE | non-polymer | 275.3 | 12 | Chemie (HTQ) | |||
| 6 | EA, FA, GA, HA, IA... (A, B, C, D, E...) | water | water | 18.0 | 1681 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 1019 - 1567 (UniProt: P23141)
| PDB | External Database | Details |
|---|---|---|
| - | Gln 362 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 363068.0 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 5851.3 | |
| All* | Total formula weight | 368919.3 |
