1MCW
THREE-DIMENSIONAL STRUCTURE OF A HYBRID LIGHT CHAIN DIMER. PROTEIN ENGINEERING OF A BINDING CAVITY
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (W) | IMMUNOGLOBULIN WEIR (LIGHT CHAIN) | polymer | 216 | 22911.4 | 1 | PIR (S25758) | Homo sapiens (human) | |
| 2 | B (M) | IMMUNOGLOBULIN MCG (LIGHT CHAIN) | polymer | 216 | 22833.1 | 1 | PIR (S14675) Pfam (PF07686) UniProt (by SIFTS) (P01709) | Homo sapiens (human) |
Sequence modifications
W: 2 - 215 (PIR: S25758)
M: 2 - 216 (PIR: S14675)
| PDB | External Database | Details |
|---|---|---|
| Val 20 | Ile 39 | conflict |
| Ala 23 | Thr 42 | conflict |
| His 25 | Ser 44 | conflict |
| Thr 26 | Ser 45 | conflict |
| Ala 30 | Gly 49 | conflict |
| Asp 31 | Gly 50 | conflict |
| Ser 32 | Tyr 51 | conflict |
| Ser 34 | Tyr 53 | conflict |
| Ile 35 | Val 54 | conflict |
| Phe 38 | Tyr 57 | conflict |
| Asp 43 | Gly 62 | conflict |
| Leu 49 | Met 68 | conflict |
| Ala 52 | Asp 71 | conflict |
| Phe 55 | Asn 74 | conflict |
| Ile 60 | Val 79 | conflict |
| Pro 61 | Ser 80 | conflict |
| Leu 62 | Asn 81 | conflict |
| Leu 81 | Gln 100 | conflict |
| Asp 83 | Glu 102 | conflict |
| Phe 89 | Tyr 108 | conflict |
| Met 91 | Thr 110 | conflict |
| Tyr 93 | Lys 112 | conflict |
| Leu 94 | Thr 113 | conflict |
| Asp 96 | - | insertion |
| Ala 97 | Ser 115 | conflict |
| - | Tyr 118 | deletion |
| Ser 103 | Thr 122 | conflict |
| Thr 108 | Ser 127 | conflict |
| Arg 111 | Gly 130 | conflict |
| Glu 160 | Lys 179 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ile 20 | Phe 39 | conflict |
| Thr 23 | Ser 42 | conflict |
| Val 29 | Ile 48 | conflict |
| Gly 31 | Asn 50 | conflict |
| Gln 39 | Arg 58 | conflict |
| Ala 42 | Pro 61 | conflict |
| Val 48 | Leu 67 | conflict |
| Ile 49 | Met 68 | conflict |
| Asn 54 | Thr 73 | conflict |
| Asp 62 | Asn 81 | conflict |
| Glu 94 | Ala 113 | conflict |
| Asp 97 | Asn 116 | conflict |
| Asn 98 | Ser 117 | conflict |
| Phe 99 | Leu 118 | conflict |
| Val 100 | Ile 119 | conflict |
| Thr 103 | Gly 122 | conflict |
| Lys 106 | Arg 125 | conflict |
| Val 107 | Leu 126 | conflict |
| Asn 116 | Ala 135 | conflict |
| Thr 118 | Ser 137 | conflict |
| Gly 156 | Ser 175 | conflict |
| Lys 167 | Thr 186 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 45744.5 | |
| All* | Total formula weight | 45744.5 |
