1MCW

THREE-DIMENSIONAL STRUCTURE OF A HYBRID LIGHT CHAIN DIMER. PROTEIN ENGINEERING OF A BINDING CAVITY

Functional Information from GO Data

Chain	GOid	namespace	contents
M	0002250	biological_process	adaptive immune response
M	0002376	biological_process	immune system process
M	0003823	molecular_function	antigen binding
M	0005576	cellular_component	extracellular region
M	0005886	cellular_component	plasma membrane
M	0006955	biological_process	immune response
M	0019814	cellular_component	immunoglobulin complex

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH

Chain	Residue	Details
M	TYR195-HIS201
W	TYR195-HIS201

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Region: {"description":"Complementarity-determining-1","evidences":[{"source":"UniProtKB","id":"P01721","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	16
Details	Region: {"description":"Framework-2","evidences":[{"source":"UniProtKB","id":"P01721","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Region: {"description":"Complementarity-determining-2","evidences":[{"source":"UniProtKB","id":"P01721","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	35
Details	Region: {"description":"Framework-3","evidences":[{"source":"UniProtKB","id":"P01721","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	21
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Region: {"description":"Complementarity-determining-3","evidences":[{"source":"UniProtKB","id":"P01721","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

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