1M9N

CRYSTAL STRUCTURE OF THE HOMODIMERIC BIFUNCTIONAL TRANSFORMYLASE AND CYCLOHYDROLASE ENZYME AVIAN ATIC IN COMPLEX WITH AICAR AND XMP AT 1.93 ANGSTROMS.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	AICAR TRANSFORMYLASE-IMP CYCLOHYDROLASE	polymer	613	66669.1	2	UniProt (P31335) Pfam (PF02142) Pfam (PF01808)	Gallus gallus (chicken)	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH [INCLUDES PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXAMIDE FORMYLTRANSFERASE (AICAR TRANSFORMYLASE) AND IMP CYCLOHYDROLASE (INOSINICASE, IMP SYNTHETASE, ATIC)]
2	C, F (A, B)	POTASSIUM ION	non-polymer		39.1	2	Chemie (K)
3	D, G (A, B)	AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE	non-polymer		338.2	2	Chemie (AMZ)
4	E, H (A, B)	XANTHOSINE-5'-MONOPHOSPHATE	non-polymer		365.2	2	Chemie (XMP)
5	I, J (A, B)	water	water		18.0	511	Chemie (HOH)

Sequence modifications

A, B: 1 - 593 (UniProt: P31335)

PDB	External Database	Details
Met -19	-	expression tag
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	insertion
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	133338.2
Non-Polymers*	Number of molecules	6
	Total formula weight	1485.0
All*	Total formula weight	134823.2

*Water molecules are not included.