1LE5

Crystal structure of a NF-kB heterodimer bound to an IFNb-kB

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (C, G)	5'-D(*TP*GP*GP*GP*AP*AP*AP*TP*TP*CP*CP*T)-3'	polymer	12	3677.4	2
2	B, D (D, H)	5'-D(*AP*AP*GP*GP*AP*AP*TP*TP*TP*CP*CP*C)-3'	polymer	12	3646.4	2
3	E, G (A, E)	Nuclear factor NF-kappa-B p65 subunit	polymer	274	31115.2	2	UniProt (Q04207) Pfam (PF00554) Pfam (PF16179)	Mus musculus (house mouse)	NF-kB p65
4	F, H (B, F)	Nuclear factor NF-kappa-B p50 subunit	polymer	313	35056.1	2	UniProt (P25799) Pfam (PF00554) Pfam (PF16179)	Mus musculus (house mouse)	NF-kB p50
5	I, J, K, L, M... (C, D, G, H, A...)	water	water		18.0	175	Chemie (HOH)

Sequence modifications

A, E: 20 - 291 (UniProt: Q04207)

PDB	External Database	Details
Met 18	-	cloning artifact
Ala 19	-	cloning artifact

B, F: 39 - 350 (UniProt: P25799)

PDB	External Database	Details
Met 38	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	146990.2
All*	Total formula weight	146990.2

*Water molecules are not included.