1LAT

GLUCOCORTICOID RECEPTOR MUTANT/DNA COMPLEX

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (C, D)	DNA (5'-D(*TP*TP*CP*CP*AP*GP*AP*AP*CP*AP*TP*GP*TP*TP*CP*TP*G P*GP*A)-3')	polymer	19	5819.8	2
2	C, D (A, B)	GLUCOCORTICOID RECEPTOR	polymer	82	9370.2	2	UniProt (P06536) Pfam (PF00105)	Rattus norvegicus (Rat)
3	E, F, G, H (A, B)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
4	I, J, K, L (C, D, A, B)	water	water		18.0	316	Chemie (HOH)

Sequence modifications

A, B: 440 - 515 (UniProt: P06536)

PDB	External Database	Details
Met 434	-	expression tag
Lys 435	-	expression tag
Pro 436	-	expression tag
Ala 437	-	expression tag
Arg 438	-	expression tag
Pro 439	-	expression tag
Glu 458	Gly 458	engineered mutation
Gly 459	Ser 459	engineered mutation
Ala 462	Val 462	engineered mutation
Lys 477	Ala 477	engineered mutation
Tyr 478	Gly 478	engineered mutation
Glu 479	Arg 479	engineered mutation
Gly 480	Asn 480	engineered mutation
Lys 481	Asp 481	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	30380.0
Non-Polymers*	Number of molecules	4
	Total formula weight	261.6
All*	Total formula weight	30641.6

*Water molecules are not included.