1KXR

Crystal Structure of Calcium-Bound Protease Core of Calpain I

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	thiol protease DOMAINS I AND II	polymer	339	38788.5	2	UniProt (P97571) Pfam (PF00648) In PDB	Rattus norvegicus (Norway rat)	calpain I protease core
2	A, B	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)
3		water	water		18.0	359	Chemie (HOH)

Sequence modifications

A, B: 27 - 356 (UniProt: P97571)

PDB	External Database	Details
Met 26	-	initiating methionine
Ser 115	Cys 115	engineered mutation
Leu 357	-	expression tag
Glu 358	-	expression tag
His 359	-	expression tag
His 360	-	expression tag
His 361	-	expression tag
His 362	-	expression tag
His 363	-	expression tag
His 364	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	77577.0
Non-Polymers*	Number of molecules	4
	Total formula weight	160.3
All*	Total formula weight	77737.3

*Water molecules are not included.