1KC2
structure of the triple (Lys(beta)D3Ala, Asp(beta)C8Ala, AspCD2Ala) mutant of the Src SH2 domain bound to the PQpYEEIPI peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Src Tyrosine kinase | polymer | 103 | 11696.2 | 1 | UniProt (P00524) Pfam (PF00017) | Rous sarcoma virus | tyrosine-protein kinase transforming protein SRC |
| 2 | B (B) | PQpYEEIPI peptide | polymer | 8 | 1068.1 | 1 | |||
| 3 | C (A) | COBALT (II) ION | non-polymer | 58.9 | 1 | Chemie (CO) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 64 | Chemie (HOH) |
Sequence modifications
A: 147 - 249 (UniProt: P00524)
| PDB | External Database | Details |
|---|---|---|
| Ala 192 | Asp 190 | engineered mutation |
| Ala 194 | Asp 192 | engineered mutation |
| Ala 202 | Lys 200 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 12764.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 58.9 | |
| All* | Total formula weight | 12823.2 |
