1K9O

CRYSTAL STRUCTURE OF MICHAELIS SERPIN-TRYPSIN COMPLEX

Replaces:  1I99

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (I)	ALASERPIN	polymer	378	42017.0	1	UniProt (P14754)	Manduca sexta (tobacco hornworm)	SERPIN 1
2	B (E)	TRYPSIN II ANIONIC	polymer	223	23798.8	1	UniProt (P00763) Pfam (PF00089)	Rattus norvegicus (Norway rat)	PRETRYPSINOGEN II
3	C, D (I, E)	water	water		18.0	182	Chemie (HOH)

Sequence modifications

I: 9 - 386 (UniProt: P14754)

PDB	External Database	Details
Thr 280	Tyr 286	SEE REMARK 999
Thr 323	Tyr 329	SEE REMARK 999
Lys 353	Ala 359	engineered mutation

E: 16 - 245 (UniProt: P00763)

PDB	External Database	Details
Ala 195	Ser 200	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	65815.8
All*	Total formula weight	65815.8

*Water molecules are not included.