1K9O

CRYSTAL STRUCTURE OF MICHAELIS SERPIN-TRYPSIN COMPLEX

Replaces:  1I99

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0004252	molecular_function	serine-type endopeptidase activity
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0006508	biological_process	proteolysis
E	0007584	biological_process	response to nutrient
E	0007586	biological_process	digestion
E	0008233	molecular_function	peptidase activity
E	0008236	molecular_function	serine-type peptidase activity
E	0016787	molecular_function	hydrolase activity
E	0030574	biological_process	collagen catabolic process
E	0046872	molecular_function	metal ion binding
I	0004867	molecular_function	serine-type endopeptidase inhibitor activity
I	0005615	cellular_component	extracellular space

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC

Chain	Residue	Details
E	VAL53-CYS58

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site_id	PS00284
Number of Residues	11
Details	SERPIN Serpins signature. VHIDRPFYFeL

Chain	Residue	Details
I	VAL361-LEU371

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system

Chain	Residue	Details
E	HIS57
E	ASP102
E	ALA195

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING:

Chain	Residue	Details
E	GLU70
E	ASN72
E	VAL75
E	GLU80

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Required for specificity => ECO:0000250

Chain	Residue	Details
E	ASP189

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