1K4T
HUMAN DNA TOPOISOMERASE I (70 KDA) IN COMPLEX WITH THE POISON TOPOTECAN AND COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B | 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3' | polymer | 10 | 3061.1 | 1 | |||
| 2 | C | 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3' | polymer | 12 | 3716.5 | 1 | |||
| 3 | D | 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3' | polymer | 22 | 6690.4 | 1 | |||
| 4 | A | DNA topoisomerase I | polymer | 592 | 70248.0 | 1 | UniProt (P11387) Pfam (PF02919) Pfam (PF01028) Pfam (PF14370) In PDB | Homo sapiens (human) | |
| 5 | C | 2-(1-DIMETHYLAMINOMETHYL-2-HYDROXY-8-HYDROXYMETHYL-9-OXO-9,11-DIHYDRO-INDOLIZINO[1,2-B]QUINOLIN-7-YL)-2-HYDROXY-BUTYRIC ACID | non-polymer | 439.5 | 1 | Chemie (TTG) | |||
| 6 | D | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE | non-polymer | 421.4 | 1 | Chemie (TTC) | |||
| 7 | A | MERCURY (II) ION | non-polymer | 200.6 | 1 | Chemie (HG) | |||
| 8 | A | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 9 | water | water | 18.0 | 227 | Chemie (HOH) |
Sequence modifications
A: 174 - 765 (UniProt: P11387)
| PDB | External Database | Details |
|---|---|---|
| Ptr 723 | Tyr 723 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 83716.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1255.7 | |
| All* | Total formula weight | 84971.7 |
