1JQE
Crystal Structure Analysis of Human Histamine Methyltransferase (Ile105 Polymorphic Variant) Complexed with AdoHcy and Antimalarial Drug Quinacrine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histamine N-Methyltransferase | polymer | 292 | 33345.1 | 2 | UniProt (P50135) Pfam (PF13489) | Homo sapiens (human) | HNMT, HMT |
| 2 | C, E (A, B) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) PubChem (16760024) PubChem (193) PubChem (13792) PubChem (177678424) PubChem (189149) PubChem (439155) PubChem (25210495) PubChem (21125603) PubChem (44361184) PubChem (25203782) PubChem (46936206) PubChem (50989525) PubChem (51380914) PubChem (52224398) PubChem (57544532) PubChem (52224400) PubChem (59046843) PubChem (59170628) PubChem (59576228) PubChem (66805708) PubChem (5284331) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (71170554) PubChem (13231890) PubChem (6419189) PubChem (118374891) PubChem (118560068) PubChem (126969526) PubChem (129105892) PubChem (164157219) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525) | |||
| 3 | D (A) | QUINACRINE | non-polymer | 400.0 | 1 | Chemie (QUN) PubChem (446536) PubChem (237) PubChem (6603979) | |||
| 4 | F, G, H, I, J... (B) | UNKNOWN ATOM OR ION | non-polymer | 7 | Chemie (UNX) | ||||
| 5 | M, N (A, B) | water | water | 18.0 | 377 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 292 (UniProt: P50135)
| PDB | External Database | Details |
|---|---|---|
| Ile 105 | Thr 105 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66690.1 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1168.8 | |
| All* | Total formula weight | 67858.9 |
