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1JQE

Crystal Structure Analysis of Human Histamine Methyltransferase (Ile105 Polymorphic Variant) Complexed with AdoHcy and Antimalarial Drug Quinacrine

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BHistamine N-Methyltransferasepolymer29233345.12UniProt (P50135)
Pfam (PF13489)
In PDB
Homo sapiens (human)HNMT, HMT
2A, BS-ADENOSYL-L-HOMOCYSTEINEnon-polymer384.42Chemie (SAH)
3AQUINACRINEnon-polymer400.01Chemie (QUN)
4BUNKNOWN ATOM OR IONnon-polymer7Chemie (UNX)
5waterwater18.0377Chemie (HOH)
Sequence modifications
A, B: 1 - 292 (UniProt: P50135)
PDBExternal DatabaseDetails
Ile 105Thr 105variant
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight66690.1
Non-Polymers*Number of molecules10
Total formula weight1168.8
All*Total formula weight67858.9
*Water molecules are not included.

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PDB entries from 2024-06-12

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