1JQE
Crystal Structure Analysis of Human Histamine Methyltransferase (Ile105 Polymorphic Variant) Complexed with AdoHcy and Antimalarial Drug Quinacrine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Histamine N-Methyltransferase | polymer | 292 | 33345.1 | 2 | UniProt (P50135) Pfam (PF13489) In PDB | Homo sapiens (human) | HNMT, HMT |
| 2 | A, B | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) | |||
| 3 | A | QUINACRINE | non-polymer | 400.0 | 1 | Chemie (QUN) | |||
| 4 | B | UNKNOWN ATOM OR ION | non-polymer | 7 | Chemie (UNX) | ||||
| 5 | water | water | 18.0 | 377 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 292 (UniProt: P50135)
| PDB | External Database | Details |
|---|---|---|
| Ile 105 | Thr 105 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66690.1 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1168.8 | |
| All* | Total formula weight | 67858.9 |
