1JD2
Crystal Structure of the yeast 20S Proteasome:TMC-95A complex: A non-covalent Proteasome Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, V (A, V) | PROTEASOME COMPONENT Y7 | polymer | 250 | 27191.8 | 2 | UniProt (P23639) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | MACROPAIN SUBUNIT Y7, PROTEINASE YSCE SUBUNIT 7, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT Y7 |
| 2 | B, W (B, W) | PROTEASOME COMPONENT Y13 | polymer | 244 | 27050.4 | 2 | UniProt (P23638) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | MACROPAIN SUBUNIT Y13, PROTEINASE YSCE SUBUNIT 13, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT Y13 |
| 3 | C, X (C, X) | PROTEASOME COMPONENT PRE6 | polymer | 241 | 26903.3 | 2 | UniProt (P40303) Pfam (PF00227) Pfam (PF10584) | Saccharomyces cerevisiae (baker's yeast) | MACROPAIN SUBUNIT PRE6, PROTEINASE YSCE SUBUNIT PRE6, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PRE6 |
| 4 | D, Y (D, Y) | PROTEASOME COMPONENT PUP2 | polymer | 242 | 26544.8 | 2 | UniProt (P32379) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | MACROPAIN SUBUNIT PUP2, PROTEINASE YSCE SUBUNIT PUP2, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PUP2 |
| 5 | E, Z (E, Z) | PROTEASOME COMPONENT PRE5 | polymer | 233 | 25502.8 | 2 | UniProt (P40302) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | MACROPAIN SUBUNIT PRE5, PROTEINASE YSCE SUBUNIT PRE5, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PRE5 |
| 6 | AA, F (F, 1) | PROTEASOME COMPONENT C1 | polymer | 244 | 26892.5 | 2 | UniProt (P21242) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | MACROPAIN SUBUNIT C1, PROTEINASE YSCE SUBUNIT 1, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT C1 |
| 7 | BA, G (G, 2) | PROTEASOME COMPONENT C7-ALPHA | polymer | 243 | 27316.0 | 2 | UniProt (P21243) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | MACROPAIN SUBUNIT C7-ALPHA, PROTEINASE YSCE SUBUNIT 7, MULTICATALYTIC ENDOPEPTIDASE COMPLEX C7, COMPONENT Y8, SCL1 SUPPRESSOR PROTEIN |
| 8 | H, O (H, O) | PROTEASOME COMPONENT PUP1 | polymer | 222 | 23987.3 | 2 | UniProt (P25043) Pfam (PF00227) Pfam (PF12465) | Saccharomyces cerevisiae (baker's yeast) | MACROPAIN SUBUNIT PUP1, PROTEINASE YSCE SUBUNIT PUP1, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PUP1 |
| 9 | I, P (I, P) | PROTEASOME COMPONENT PUP3 | polymer | 204 | 22496.6 | 2 | UniProt (P25451) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | MACROPAIN SUBUNIT PUP3, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PUP3 |
| 10 | J, Q (J, Q) | PROTEASOME COMPONENT C11 | polymer | 198 | 22545.7 | 2 | UniProt (P22141) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | MACROPAIN SUBUNIT C11, PROTEINASE YSCE SUBUNIT 11, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT C11 |
| 11 | K, R (K, R) | PROTEASOME COMPONENT PRE2 | polymer | 212 | 23325.2 | 2 | UniProt (P30656) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | MACROPAIN SUBUNIT PRE2, PROTEINASE YSCE SUBUNIT PRE2, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PRE2 |
| 12 | L, S (L, S) | PROTEASOME COMPONENT C5 | polymer | 222 | 24883.9 | 2 | UniProt (P23724) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT C5 |
| 13 | M, T (M, T) | PROTEASOME COMPONENT PRE4 | polymer | 233 | 25945.5 | 2 | UniProt (P30657) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | MACROPAIN SUBUNIT PRE4, PROTEINASE YSCE SUBUNIT PRE4, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PRE4 |
| 14 | N, U (N, U) | PROTEASOME COMPONENT PRE3 | polymer | 196 | 21517.2 | 2 | UniProt (P38624) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | MACROPAIN SUBUNIT PRE3, PROTEINASE YSCE SUBUNIT PRE3, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PRE3 |
| 15 | CA, DA (8, 9) | TMC-95A inhibitor | polymer | 5 | 680.7 | 2 | BIRD (PRD_001096) | Apiospora montagnei | |
| 16 | EA, FA, GA, HA, IA... (D, F, G, H, I...) | MAGNESIUM ION | non-polymer | 24.3 | 10 | Chemie (MG) | |||
| 17 | AB, BB, CB, DB, EB... (M, N, O, P, Q...) | water | water | 18.0 | 2893 | Chemie (HOH) |
Sequence modifications
D, Y: 9 - 244 (UniProt: P32379)
E, Z: 4 - 233 (UniProt: P40302)
| PDB | External Database | Details |
|---|---|---|
| Leu 121 | - | INSERTION |
| Arg 122 | - | INSERTION |
| Phe 123 | - | INSERTION |
| Gly 123 | - | INSERTION |
| Glu 123 | - | INSERTION |
| Gly 123 | - | INSERTION |
| Ser 123 | - | INSERTION |
| Gly 123 | - | INSERTION |
| Glu 123 | - | INSERTION |
| Glu 125 | Ala 122 | CONFLICT |
| Arg 126 | Ala 123 | CONFLICT |
| Leu 127 | Ala 124 | CONFLICT |
| PDB | External Database | Details |
|---|---|---|
| Tyr 127 | Ala 123 | CONFLICT |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 30 |
| Total formula weight | 705567.7 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 243.1 | |
| All* | Total formula weight | 705810.7 |
