1I4E

CRYSTAL STRUCTURE OF THE CASPASE-8/P35 COMPLEX

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Early 35 kDa protein	polymer	299	34768.5	1	UniProt (P08160) Pfam (PF02331)	Autographa californica nucleopolyhedrovirus (AcMNPV)	p35, Apoptosis-preventing protein
2	B (B)	Caspase-8	polymer	258	29522.6	1	UniProt (Q14790) Pfam (PF00656)	Homo sapiens (human)	CASP-8, ICE-like apoptotic protease 5, MORT1-associated ced-3 homolog, MACH, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, FLICE, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, Caspase-8 subunit p18, Caspase-8 subunit p10

Sequence modifications

A: 2 - 299 (UniProt: P08160)

PDB	External Database	Details
Ace 1	-	acetylation

B: 2222 - 2479 (UniProt: Q14790)

PDB	External Database	Details
His 2285	Asp 285	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	64291.1
All*	Total formula weight	64291.1

*Water molecules are not included.