1I3K
MOLECULAR BASIS FOR SEVERE EPIMERASE-DEFICIENCY GALACTOSEMIA: X-RAY STRUCTURE OF THE HUMAN V94M-SUBSTITUTED UDP-GALACTOSE 4-EPIMERASE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | UDP-GLUCOSE 4-EPIMERASE | polymer | 348 | 38384.7 | 2 | UniProt (Q14376) Pfam (PF16363) | Homo sapiens (human) | UDP-GALACTOSE 4-EPIMERASE |
| 2 | C, H, I, J (A, B) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) PubChem (312) | |||
| 3 | D (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 4 | E, K (A, B) | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 2 | Chemie (NAD) | |||
| 5 | F, L (A, B) | URIDINE-5'-DIPHOSPHATE-GLUCOSE | non-polymer | 566.3 | 2 | Chemie (UPG) PubChem (1166) PubChem (439156) PubChem (448801) PubChem (6857540) PubChem (12133414) PubChem (13008857) PubChem (13987142) PubChem (16667381) PubChem (20776702) PubChem (20776703) PubChem (25011746) PubChem (45109771) PubChem (46226441) PubChem (46936243) PubChem (16760700) PubChem (20776705) PubChem (20776706) PubChem (23724458) PubChem (56650783) PubChem (56846106) PubChem (8629) PubChem (18068) PubChem (439158) PubChem (448873) PubChem (640055) PubChem (92328335) PubChem (92974127) PubChem (53477679) PubChem (6857410) PubChem (56845790) PubChem (124933210) PubChem (129850353) PubChem (11734460) PubChem (58538034) PubChem (155893098) PubChem (158571248) PubChem (162920685) PubChem (168265389) PubChem (59720988) PubChem (88869506) PubChem (88869507) PubChem (88869743) PubChem (88870643) PubChem (88883029) PubChem (88910951) PubChem (88941526) PubChem (89321600) PubChem (89360378) PubChem (89847362) PubChem (90056247) PubChem (90950359) PubChem (91746280) PubChem (92974126) PubChem (92974128) PubChem (92974129) PubChem (93535589) PubChem (102429624) PubChem (124933209) PubChem (134736387) PubChem (134736388) PubChem (138911444) PubChem (162920683) PubChem (162920684) PubChem (163626061) PubChem (166642644) PubChem (168720052) PubChem (174027848) | |||
| 6 | G, M, N (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 7 | O, P (A, B) | water | water | 18.0 | 977 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 348 (UniProt: Q14376)
| PDB | External Database | Details |
|---|---|---|
| Met 94 | Val 94 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 76769.5 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2811.8 | |
| All* | Total formula weight | 79581.2 |
