1I1A
CRYSTAL STRUCTURE OF THE NEONATAL FC RECEPTOR COMPLEXED WITH A HETERODIMERIC FC
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NEONATAL FC RECEPTOR A | polymer | 269 | 30322.9 | 1 | UniProt (P13599) Pfam (PF00129) Pfam (PF07654) | Rattus norvegicus (Norway rat) | IGG RECEPTOR FCRN LARGE SUBUNIT P51, FCRN |
| 2 | B (B) | BETA-2-MICROGLOBULIN | polymer | 99 | 11652.3 | 1 | UniProt (P07151) Pfam (PF07654) | Rattus norvegicus (Norway rat) | HDFC |
| 3 | C (C) | IG GAMMA-2A CHAIN C REGION | polymer | 225 | 25248.5 | 1 | UniProt (P20760) Pfam (PF07654) | Rattus norvegicus (Norway rat) | WTFC |
| 4 | D (D) | IG GAMMA-2A CHAIN C REGION | polymer | 239 | 26650.9 | 1 | UniProt (P20760) Pfam (PF07654) | Rattus norvegicus (Norway rat) | NBFC |
| 5 | E (E) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 1 | In PDB GlyTouCan (G86851RC) | |||
| 6 | F (F) | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1098.0 | 1 | In PDB GlyTouCan (G97864SE) | |||
| 7 | G (G) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1463.3 | 1 | In PDB GlyTouCan (G59451NL) | |||
| 8 | H (H) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1463.3 | 1 | In PDB GlyTouCan (G80858MF) | |||
| 9 | I, J (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 10 | K, L (A) | CYSTEINE | non-polymer | 121.2 | 2 | Chemie (CYS) | |||
| 11 | M, N, O (A, B, C) | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
D: 223 - 447 (UniProt: P20760)
| PDB | External Database | Details |
|---|---|---|
| Gly 252 | Thr 127 | engineered mutation |
| Gly 253 | Ile 128 | engineered mutation |
| Gly 254 | Thr 129 | engineered mutation |
| Glu 310 | His 185 | engineered mutation |
| Glu 433 | His 308 | engineered mutation |
| Glu 435 | His 310 | engineered mutation |
| Gly 448 | - | cloning artifact |
| Ile 449 | - | cloning artifact |
| Glu 450 | - | cloning artifact |
| Gly 451 | - | cloning artifact |
| Arg 452 | - | cloning artifact |
| Gly 453 | - | cloning artifact |
| Ser 454 | - | cloning artifact |
| Ser 455 | - | cloning artifact |
| His 456 | - | cloning artifact |
| His 457 | - | cloning artifact |
| His 458 | - | cloning artifact |
| His 459 | - | cloning artifact |
| His 460 | - | cloning artifact |
| His 461 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 93874.5 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 4392.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 684.7 | |
| All* | Total formula weight | 98951.3 |
