1I00
CRYSTAL STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE, TERNARY COMPLEX WITH DUMP AND TOMUDEX
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | THYMIDYLATE SYNTHASE | polymer | 290 | 33189.1 | 2 | UniProt (P04818) Pfam (PF00303) | Homo sapiens (human) | |
| 2 | C, E (A, B) | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE | non-polymer | 308.2 | 2 | Chemie (UMP) | |||
| 3 | D, F (A, B) | TOMUDEX | non-polymer | 458.5 | 2 | Chemie (D16) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 110 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 313 (UniProt: P04818)
| PDB | External Database | Details |
|---|---|---|
| - | Glu 6 | deletion |
| - | Leu 7 | deletion |
| - | Pro 8 | deletion |
| - | Arg 9 | deletion |
| - | Arg 10 | deletion |
| - | Pro 11 | deletion |
| - | Leu 12 | deletion |
| - | Pro 13 | deletion |
| - | Pro 14 | deletion |
| - | Ala 15 | deletion |
| - | Ala 16 | deletion |
| - | Gln 17 | deletion |
| - | Glu 18 | deletion |
| - | Arg 19 | deletion |
| - | Asp 20 | deletion |
| - | Ala 21 | deletion |
| - | Glu 22 | deletion |
| - | Pro 23 | deletion |
| - | Arg 24 | deletion |
| - | Pro 25 | deletion |
| - | Pro 26 | deletion |
| - | His 27 | deletion |
| - | Gly 28 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66378.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1533.3 | |
| All* | Total formula weight | 67911.5 |
