1HW4
STRUCTURE OF THYMIDYLATE SYNTHASE SUGGESTS ADVANTAGES OF CHEMOTHERAPY WITH NONCOMPETITIVE INHIBITORS
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | THYMIDYLATE SYNTHASE | polymer | 355 | 40916.9 | 1 | UniProt (P04818) Pfam (PF00303) | Homo sapiens (human) | TS |
| 2 | B, C, D (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 3 | E (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | F (A) | water | water | 18.0 | 102 | Chemie (HOH) |
Sequence modifications
A: 1 - 313 (UniProt: P04818)
| PDB | External Database | Details |
|---|---|---|
| Cme 43 | Cys 42 | modified residue |
| Cme 180 | Cys 179 | modified residue |
| Cme 199 | Cys 198 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40916.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 350.3 | |
| All* | Total formula weight | 41267.1 |
