1HVR
RATIONAL DESIGN OF POTENT, BIOAVAILABLE, NONPEPTIDE CYCLIC UREAS AS HIV PROTEASE INHIBITORS
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | HIV-1 PROTEASE | polymer | 99 | 10773.7 | 2 | UniProt (P04585) Pfam (PF00077) | Human immunodeficiency virus 1 | |
| 2 | C (A) | [4R-(4ALPHA,5ALPHA,6BETA,7BETA)]-HEXAHYDRO-5,6-DIHYDROXY-1,3-BIS[2-NAPHTHYL-METHYL]-4,7-BIS(PHENYLMETHYL)-2H-1,3-DIAZEPIN-2-ONE | non-polymer | 606.8 | 1 | Chemie (XK2) |
Sequence modifications
A, B: 1 - 99 (UniProt: P04585)
| PDB | External Database | Details |
|---|---|---|
| Ala 95 | Cys 151 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21547.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 606.8 | |
| All* | Total formula weight | 22154.1 |
