1HUW

THE CRYSTAL STRUCTURE OF AFFINITY-MATURED HUMAN GROWTH HORMONE AT 2 ANGSTROMS RESOLUTION

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	HUMAN GROWTH HORMONE	polymer	191	21986.6	1	UniProt (P01241) Pfam (PF00103)	Homo sapiens (human)
2	B (A)	water	water		18.0	77	Chemie (HOH)

Sequence modifications

A: 1 - 191 (UniProt: P01241)

PDB	External Database	Details
Ala 10	Phe 36	engineered mutation
Trp 14	Met 40	engineered mutation
Asp 18	His 44	engineered mutation
Asn 21	His 47	engineered mutation
Ile 41	Lys 67	engineered mutation
His 42	Tyr 68	engineered mutation
Trp 45	Leu 71	engineered mutation
Trp 46	Gln 72	engineered mutation
Pro 54	Phe 80	engineered mutation
Lys 64	Arg 90	engineered mutation
Asn 167	Arg 193	engineered mutation
Ser 171	Asp 197	engineered mutation
Ser 174	Glu 200	engineered mutation
Tyr 176	Phe 202	engineered mutation
Thr 179	Ile 205	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	21986.6
All*	Total formula weight	21986.6

*Water molecules are not included.