1H2U
Structure of the human nuclear cap-binding-complex (CBC) in complex with a cap analogue m7GpppG
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 80 KDA NUCLEAR CAP BINDING PROTEIN | polymer | 723 | 83835.2 | 2 | UniProt (Q09161) Pfam (PF02854) Pfam (PF09088) Pfam (PF09090) | HOMO SAPIENS (HUMAN) | NCBP 80 KDA SUBUNIT, CBP80 |
| 2 | C, D (X, Y) | 20 KDA NUCLEAR CAP BINDING PROTEIN | polymer | 156 | 18028.1 | 2 | UniProt (P52298) Pfam (PF00076) | HOMO SAPIENS (HUMAN) | CBP20, NCBP 20 KDA SUBUNIT, NCBP INTERACTING PROTEIN 1, NIP1 |
| 3 | E, G (X, Y) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 4 | F, H (X, Y) | 7N-METHYL-8-HYDROGUANOSINE-5'-MONOPHOSPHATE | non-polymer | 379.3 | 2 | Chemie (7MG) PubChem (135497480) PubChem (135509071) PubChem (136254608) | |||
| 5 | I, J, K, L (A, B, X, Y) | water | water | 18.0 | 1317 | Chemie (HOH) |
Sequence modifications
A, B: 20 - 652 (UniProt: Q09161)
A, B: 702 - 790 (UniProt: Q09161)
A, B: 653 - 653 (PDB: 1H2U)
| PDB | External Database | Details |
|---|---|---|
| Ser 479 | Ala 479 | engineered mutation |
A, B: 653 - 653 (PDB: 1H2U)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 203726.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1644.9 | |
| All* | Total formula weight | 205371.7 |
