1H2U

Structure of the human nuclear cap-binding-complex (CBC) in complex with a cap analogue m7GpppG

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	80 KDA NUCLEAR CAP BINDING PROTEIN	polymer	723	83835.2	2	UniProt (Q09161) Pfam (PF02854) Pfam (PF09088) Pfam (PF09090)	HOMO SAPIENS (HUMAN)	NCBP 80 KDA SUBUNIT, CBP80
2	C, D (X, Y)	20 KDA NUCLEAR CAP BINDING PROTEIN	polymer	156	18028.1	2	UniProt (P52298) Pfam (PF00076)	HOMO SAPIENS (HUMAN)	CBP20, NCBP 20 KDA SUBUNIT, NCBP INTERACTING PROTEIN 1, NIP1
3	E, G (X, Y)	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	2	Chemie (GDP)
4	F, H (X, Y)	7N-METHYL-8-HYDROGUANOSINE-5'-MONOPHOSPHATE	non-polymer		379.3	2	Chemie (7MG)
5	I, J, K, L (A, B, X, Y)	water	water		18.0	1317	Chemie (HOH)

Sequence modifications

A, B: 20 - 652 (UniProt: Q09161)

PDB	External Database	Details
Ser 479	Ala 479	engineered mutation

A, B: 702 - 790 (UniProt: Q09161)
A, B: 653 - 653 (PDB: 1H2U)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	203726.7
Non-Polymers*	Number of molecules	4
	Total formula weight	1644.9
All*	Total formula weight	205371.7

*Water molecules are not included.