1GZL
Crystal structure of C14linkmid/IQN17: a cross-linked inhibitor of HIV-1 entry bound to the gp41 hydrophobic pocket
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | FUSION PROTEIN BETWEEN THE HYDROPHOBIC POCKET OF HIV GP41 AND GENERAL CONTROL PROTEIN GCN4-PIQI | polymer | 46 | 5468.6 | 2 | UniProt (P03069) UniProt (P04578) Pfam (PF07716) | SACCHAROMYCES CEREVISIAE | |
| 2 | C, D (C, D) | ENVELOPE GLYCOPROTEIN GP41 | polymer | 12 | 1670.7 | 2 | UniProt (P04578) | HUMAN IMMUNODEFICIENCY VIRUS | C14LINKMID |
| 3 | E, F (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) PubChem (312) | |||
| 4 | G, H (C, D) | PENTANE-1,5-DIAMINE | non-polymer | 102.2 | 2 | Chemie (N2P) PubChem (273) | |||
| 5 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 77 | Chemie (HOH) |
Sequence modifications
A, B: 0 - 0 (PDB: 1GZL)
A, B: 1 - 28 (UniProt: P03069)
A, B: 29 - 45 (UniProt: P04578)
C, D: 628 - 639 (UniProt: P04578)
A, B: 1 - 28 (UniProt: P03069)
| PDB | External Database | Details |
|---|---|---|
| Ile 5 | Leu 253 | conflict |
| Ile 9 | Val 257 | conflict |
| Ile 12 | Leu 260 | conflict |
| Glu 13 | Leu 261 | conflict |
| Gln 16 | Asn 264 | conflict |
| Lys 17 | Tyr 265 | conflict |
| Lys 18 | His 266 | conflict |
| Ile 19 | Leu 267 | conflict |
| Ile 23 | Val 271 | conflict |
| Ile 26 | Leu 274 | conflict |
C, D: 628 - 639 (UniProt: P04578)
| PDB | External Database | Details |
|---|---|---|
| Glu 629 | Met 629 | engineered mutation |
| Glu 636 | Asn 636 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 14278.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 275.3 | |
| All* | Total formula weight | 14553.8 |
