1GZ3
Molecular mechanism for the regulation of human mitochondrial NAD(P)+-dependent malic enzyme by ATP and fumarate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | NAD-dependent malic enzyme, mitochondrial | polymer | 554 | 62160.4 | 4 | UniProt (P23368) Pfam (PF00390) Pfam (PF03949) | Homo sapiens (Human) | NAD-ME,Malic enzyme 2 |
| 2 | E, I, M, Q (A, B, C, D) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 4 | Chemie (ATP) | |||
| 3 | F, J, N, R (A, B, C, D) | OXALATE ION | non-polymer | 88.0 | 4 | Chemie (OXL) | |||
| 4 | G, K, O, S (A, B, C, D) | MANGANESE (II) ION | non-polymer | 54.9 | 4 | Chemie (MN) | |||
| 5 | H, L, P, T (A, B, C, D) | FUMARIC ACID | non-polymer | 116.1 | 4 | Chemie (FUM) | |||
| 6 | U, V, W, X (A, B, C, D) | water | water | 18.0 | 1157 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 20 - 573 (UniProt: P23368)
| PDB | External Database | Details |
|---|---|---|
| Gln 197 | Arg 197 | engineered mutation |
| Val 542 | Arg 542 | engineered mutation |
| Gln 556 | Arg 556 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 248641.7 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 3064.8 | |
| All* | Total formula weight | 251706.5 |
