1GXD
proMMP-2/TIMP-2 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 72 KDA TYPE IV COLLAGENASE | polymer | 631 | 70995.4 | 2 | UniProt (P08253) Pfam (PF00413) Pfam (PF00040) Pfam (PF00045) | HOMO SAPIENS (HUMAN) | GELATINASE A, 72 KDA GELATINASE, MATRIX METALLOPROTEINASE-2, MMP-2, TBE-1 |
| 2 | C, D (C, D) | METALLOPROTEINASE INHIBITOR 2 | polymer | 194 | 21783.0 | 2 | UniProt (P16035) Pfam (PF00965) | HOMO SAPIENS (HUMAN) | TISSUE INHIBITOR OF METALLOPROTEINASES-2, TIMP-2 |
| 3 | E, I (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | F, G, J, K (A, B) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 5 | H, L (A, B) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) |
Sequence modifications
A, B: 1 - 631 (UniProt: P08253)
| PDB | External Database | Details |
|---|---|---|
| Ala 375 | Glu 404 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 185556.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 533.9 | |
| All* | Total formula weight | 186090.8 |
