1FVE
X-RAY STRUCTURES OF THE ANTIGEN-BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI-P185-HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | IGG1-KAPPA 4D5 FAB (LIGHT CHAIN) | polymer | 214 | 23432.0 | 2 | EMBL (X95750) | Homo sapiens (human) | |
2 | B, D | IGG1-KAPPA 4D5 FAB (HEAVY CHAIN) | polymer | 223 | 23744.6 | 2 | EMBL (Y14735) | Homo sapiens (human) | |
3 | water | water | 18.0 | 51 | Chemie (HOH) |
Sequence modifications
A, C: 4 - 214 (EMBL: X95750)
B, D: 2 - 223 (EMBL: Y14735)
PDB | External Database | Details |
---|---|---|
Ser 14 | Phe 36 | CONFLICT |
Asp 28 | Ser 50 | CONFLICT |
Val 29 | Ile 51 | CONFLICT |
Asn 30 | Ser 52 | CONFLICT |
Thr 31 | Ser 53 | CONFLICT |
Ala 32 | Tyr 54 | CONFLICT |
Val 33 | Leu 55 | CONFLICT |
Ala 34 | Asn 56 | CONFLICT |
Ser 50 | Ala 72 | CONFLICT |
Phe 53 | Ser 75 | CONFLICT |
Glu 55 | Gln 77 | CONFLICT |
Arg 66 | Gly 88 | CONFLICT |
His 91 | Ser 113 | CONFLICT |
Tyr 92 | His 114 | CONFLICT |
Thr 93 | Ser 115 | CONFLICT |
Pro 96 | Tyr 118 | CONFLICT |
Lys 103 | Asn 125 | CONFLICT |
Val 104 | Leu 126 | CONFLICT |
PDB | External Database | Details |
---|---|---|
Asn 28 | Ala 47 | CONFLICT |
Ile 29 | Tyr 48 | CONFLICT |
Lys 30 | Ser 49 | CONFLICT |
Asp 31 | Ser 50 | CONFLICT |
Thr 32 | Phe 51 | CONFLICT |
Tyr 33 | Trp 52 | CONFLICT |
Ile 34 | Met 53 | CONFLICT |
Lys 43 | Arg 62 | CONFLICT |
Glu 46 | Val 65 | CONFLICT |
Ala 49 | Ser 68 | CONFLICT |
Tyr 52 | Asn 71 | CONFLICT |
Thr 54 | Asp 73 | CONFLICT |
Asn 55 | Gly 74 | CONFLICT |
Gly 56 | Arg 75 | CONFLICT |
Tyr 57 | Ile 76 | CONFLICT |
Arg 59 | Val 78 | CONFLICT |
Ser 63 | Ala 82 | CONFLICT |
Ala 72 | Arg 91 | CONFLICT |
Thr 74 | Asn 93 | CONFLICT |
Ser 75 | Ala 94 | CONFLICT |
Ala 79 | Leu 98 | CONFLICT |
Ser 85 | Asn 104 | CONFLICT |
Ser 97 | Ala 116 | CONFLICT |
Trp 99 | - | INSERTION |
Gly 100 | - | INSERTION |
Asp 102 | Thr 119 | CONFLICT |
Gly 103 | Arg 120 | CONFLICT |
- | Leu 122 | DELETION |
- | Glu 123 | DELETION |
- | Leu 124 | DELETION |
- | Thr 125 | DELETION |
- | Ser 126 | DELETION |
- | Arg 127 | DELETION |
Tyr 105 | Gly 128 | CONFLICT |
Ala 106 | Gln 129 | CONFLICT |
Tyr 109 | Gln 132 | CONFLICT |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 94353.1 | |
All* | Total formula weight | 94353.1 |