1FVD
X-RAY STRUCTURES OF THE ANTIGEN-BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI-P185-HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | IGG1-KAPPA 4D5 FAB (LIGHT CHAIN) | polymer | 214 | 23432.0 | 2 | EMBL (X95750) | Homo sapiens (human) | |
| 2 | B, D (B, D) | IGG1-KAPPA 4D5 FAB (HEAVY CHAIN) | polymer | 223 | 23722.6 | 2 | EMBL (Y14735) | Homo sapiens (human) | |
| 3 | E, F, G, H (A, B, C, D) | water | water | 18.0 | 199 | Chemie (HOH) |
Sequence modifications
A, C: 4 - 214 (EMBL: X95750)
B, D: 2 - 223 (EMBL: Y14735)
| PDB | External Database | Details |
|---|---|---|
| Ser 14 | Phe 36 | conflict |
| Asp 28 | Ser 50 | conflict |
| Val 29 | Ile 51 | conflict |
| Asn 30 | Ser 52 | conflict |
| Thr 31 | Ser 53 | conflict |
| Ala 32 | Tyr 54 | conflict |
| Val 33 | Leu 55 | conflict |
| Ala 34 | Asn 56 | conflict |
| Ser 50 | Ala 72 | conflict |
| Phe 53 | Ser 75 | conflict |
| Glu 55 | Gln 77 | conflict |
| Arg 66 | Gly 88 | conflict |
| His 91 | Ser 113 | conflict |
| Tyr 92 | His 114 | conflict |
| Thr 93 | Ser 115 | conflict |
| Pro 96 | Tyr 118 | conflict |
| Lys 103 | Asn 125 | conflict |
| Val 104 | Leu 126 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Asn 28 | Ala 47 | conflict |
| Ile 29 | Tyr 48 | conflict |
| Lys 30 | Ser 49 | conflict |
| Asp 31 | Ser 50 | conflict |
| Thr 32 | Phe 51 | conflict |
| Tyr 33 | Trp 52 | conflict |
| Ile 34 | Met 53 | conflict |
| Lys 43 | Arg 62 | conflict |
| Glu 46 | Val 65 | conflict |
| Ala 49 | Ser 68 | conflict |
| Tyr 52 | Asn 71 | conflict |
| Thr 54 | Asp 73 | conflict |
| Asn 55 | Gly 74 | conflict |
| Gly 56 | Arg 75 | conflict |
| Tyr 57 | Ile 76 | conflict |
| Arg 59 | Val 78 | conflict |
| Ser 63 | Ala 82 | conflict |
| Ala 72 | Arg 91 | conflict |
| Thr 74 | Asn 93 | conflict |
| Ser 75 | Ala 94 | conflict |
| Ser 85 | Asn 104 | conflict |
| Ser 97 | Ala 116 | conflict |
| Trp 99 | - | insertion |
| Gly 100 | - | insertion |
| Asp 102 | Thr 119 | conflict |
| Gly 103 | Arg 120 | conflict |
| - | Leu 122 | deletion |
| - | Glu 123 | deletion |
| - | Leu 124 | deletion |
| - | Thr 125 | deletion |
| - | Ser 126 | deletion |
| - | Arg 127 | deletion |
| Tyr 105 | Gly 128 | conflict |
| Ala 106 | Gln 129 | conflict |
| Val 109 | Gln 132 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 94309.2 | |
| All* | Total formula weight | 94309.2 |
