1FVC
X-RAY STRUCTURES OF THE ANTIGEN-BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI-P185-HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | IGG1-KAPPA 4D5 FV (LIGHT CHAIN) | polymer | 109 | 11964.3 | 2 | GenBank (185985) | Homo sapiens (human) | |
| 2 | B, D (B, D) | IGG1-KAPPA 4D5 FV (HEAVY CHAIN) | polymer | 120 | 13176.6 | 2 | Homo sapiens (human) | ||
| 3 | E, F, G, H (A, B, C, D) | water | water | 18.0 | 126 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 109 (GenBank: 185985)
| PDB | External Database | Details |
|---|---|---|
| Asp 28 | Ser 50 | conflict |
| Val 29 | Ile 51 | conflict |
| Asn 30 | Ser 52 | conflict |
| Thr 31 | Ser 53 | conflict |
| Ala 32 | Tyr 54 | conflict |
| Val 33 | Leu 55 | conflict |
| Ala 34 | Asn 56 | conflict |
| Ser 50 | Ala 72 | conflict |
| Phe 53 | Ser 75 | conflict |
| Tyr 55 | Gln 77 | conflict |
| Arg 66 | Gly 88 | conflict |
| His 91 | Ser 113 | conflict |
| Thr 93 | Ser 115 | conflict |
| - | Trp 119 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 50281.9 | |
| All* | Total formula weight | 50281.9 |
