1FRP

CRYSTAL STRUCTURE OF FRUCTOSE-1,6-BISPHOSPHATASE COMPLEXED WITH FRUCTOSE-2,6-BISPHOSPHATE, AMP AND ZN2+ AT 2.0 ANGSTROMS RESOLUTION. ASPECTS OF SYNERGISM BETWEEN INHIBITORS

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	FRUCTOSE 1,6-BISPHOSPHATASE	polymer	335	36487.0	2	UniProt (P00636) Pfam (PF00316) Pfam (PF18913)	Sus scrofa (pig)
2	C, F (A, B)	2,6-di-O-phosphono-beta-D-fructofuranose	non-polymer		340.1	2	Chemie (FDP) PubChem (45109803) PubChem (50990584) PubChem (105021) PubChem (483) PubChem (15764443) PubChem (124519606) PubChem (124519607) PubChem (5460366) PubChem (124931522) PubChem (9949812) PubChem (137794960) PubChem (162979383)
3	D, G (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
4	E, H (A, B)	ADENOSINE MONOPHOSPHATE	non-polymer		347.2	2	Chemie (AMP) PubChem (16397049) PubChem (16760266) PubChem (40467049) PubChem (40469468) PubChem (44348067) PubChem (45358029) PubChem (46874558) PubChem (40459109) PubChem (46875232) PubChem (177678969) PubChem (6083) PubChem (57358045) PubChem (57879893) PubChem (57879902) PubChem (1549371) PubChem (92144436) PubChem (224) PubChem (12358354) PubChem (34768) PubChem (83862) PubChem (446048) PubChem (515384) PubChem (638042) PubChem (122197642) PubChem (5316444) PubChem (5742864) PubChem (12163610) PubChem (12358355) PubChem (162290139) PubChem (162946266) PubChem (171699505)
5	I, J (A, B)	water	water		18.0	239	Chemie (HOH)

Sequence modifications

A, B: 1 - 335 (UniProt: P00636)

PDB	External Database	Details
Gln 20	Glu 20	conflict
Ala 62	Ser 62	conflict
Thr 96	Ser 96	conflict
Asn 199	Asp 199	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	72974.0
Non-Polymers*	Number of molecules	6
	Total formula weight	1505.5
All*	Total formula weight	74479.5

*Water molecules are not included.