1FE8
CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR A3 DOMAIN IN COMPLEX WITH A FAB FRAGMENT OF IGG RU5 THAT INHIBITS COLLAGEN BINDING
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D, G (A, B, C) | VON WILLEBRAND FACTOR | polymer | 196 | 21025.2 | 3 | UniProt (P04275) Pfam (PF00092) | Homo sapiens (human) | |
| 2 | B, E, H (H, I, J) | IMMUNOGLOBULIN IGG RU5 | polymer | 210 | 22420.0 | 3 | Pfam (PF07654) UniProt (by SIFTS) (P01863) | Mus musculus (house mouse) | |
| 3 | C, F, I (L, M, N) | IMMUNOGLOBULIN IGG RU5 | polymer | 211 | 23192.4 | 3 | Mus musculus (house mouse) | ||
| 4 | J, K, L (D, E, F) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 3 | In PDB GlyTouCan (G86851RC) | |||
| 5 | M, O (H, I) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 6 | N (L) | CACODYLATE ION | non-polymer | 137.0 | 1 | Chemie (CAC) | |||
| 7 | P, Q, R, S, T... (A, H, L, B, I...) | water | water | 18.0 | 878 | Chemie (HOH) |
Sequence modifications
A, B, C: 920 - 1111 (UniProt: P04275)
| PDB | External Database | Details |
|---|---|---|
| Gly 916 | - | cloning artifact |
| Ser 917 | - | cloning artifact |
| His 918 | - | cloning artifact |
| Mse 919 | - | cloning artifact |
| Mse 947 | Met 1710 | modified residue |
| Mse 998 | Met 1761 | modified residue |
| Mse 1022 | Met 1785 | modified residue |
| Mse 1097 | Met 1860 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 199912.9 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1102.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 579.4 | |
| All* | Total formula weight | 201594.3 |
